Rapid Purification of Drug Enantiomers using Supercritical Fluid Chromatographic Method: Ibuprofen as a Model Compound

Abstract: Background: The purification of drug enantiomers is an essential technique because pharmacological activity differs depending on individual enantiomers. Nowadays, supercritical fluid technology utilized for various purposes in the pharmaceutical field. Methodology: In this study, efficient and streamlined method development strategy finding effective analytical chromatography (SFC) presented detail scaling up to preparative scale achieving enantiomerically pure product, using ibuprofen as a model compound. Results: Through optimized presented, (R) enantiomer commercial racemate can be obtained with recovery yield 80.0% enantiomeric excess 95.1 (S) 77.6% 99.3, respectively. Conclusion: use SFC systems has advantages over conventional terms separation time, reduced solvent consumption high productivity ibuprofen's purification. Key words: Ibuprofen, Analytical (Analytic-SFC), Preparative (Prep-SFC), Drug, Enantiomer, Purification.